Relationship between chronotropic incompetence and β-blockers based on changes in chronotropic response during cardiopulmonary exercise testing

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Relationship between chronotropic incompetence and β-blockers based on changes in chronotropic response during cardiopulmonary exercise testing☆

BACKGROUND Chronotropic incompetence (CI), an attenuated heart rate (HR) response to exercise, is common in patients with cardiovascular disease. The aim of this study was to assess changes in the chronotropic response (CR) during cardiopulmonary exercise testing (CPET) in patients undergoing cardiac rehabilitation and investigate the effects of β-blockers. METHODS Patients undergoing cardiac...

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[Effects of cimetidine on chronotropic response to cardiopulmonary exercise testing].

OBJECTIVE To test the hypothesis that the administration of cimetidine will modify the chronotropic response to exercise testing through a random clinical trial. METHODS The study selected 24 eligible healthy subjects, ages between 20 and 68 years, not athletes, who agreed to undergo cardiopulmonary exercise testing after the administration of placebo and 400 mg of cimetidine twice a day for ...

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Chronotropic Incompetence in Diabetic Elderly on Echocardiography

For practical purpose, most studies define CI as the incapacity to reach 80% of heart rate (HR) reserve according to the formula: HR reserve = (peak HR – resting HR) / (maximum HR – resting HR) x 100. It has been suggested that the definition of CI should be assessed when the diagnostic method uses positive inotropic drugs to induce HR increase. It is necessary to better understand which practi...

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Chronotropic incompetence in heart failure.

The relationship between heart rate (HR) during exercise and exercise capacity in patients with heart failure due to left ventricular systolic dysfunction remains unclear. The accepted diagnostic criterion for chronotropic incompetence (CI), a maximum agepredicted heart rate (MA-PHR) 85%, is seen in 50% of patients with severe heart failure on contemporary medical therapy (1). Whether the lesse...

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Chronotropic incompetence: a never-ending story.

A clear association between chronotropic incompetence and increased mortality has been established by a variety of studies in patients with coronary artery disease as well as in healthy individuals. These results gave rise to speculation that rate responsive stimulation might improve prognosis in pacemaker (PM) patients with concomitant chronotropic incompetence. To date, however, no study was ...

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ژورنال

عنوان ژورنال: IJC Heart & Vasculature

سال: 2015

ISSN: 2352-9067

DOI: 10.1016/j.ijcha.2014.11.002